While there are other options, CSS is the easiest, most reliable, accessible and straightforward way to improve the readability and visual design of your sites. The only thing in your way is an awareness of the techniques at your disposal and an understanding of when to apply them. From line-height to letter-spacing, you have more control than you might think.

http://www.digital-web.com/articles/css_typography/

with particular attention to

http://typetester.maratz.com/